18-[2-[4-(Isopropyl)thiazol-2-yl]-7-methoxyquinolin-4-yloxy]-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-ene-4-carboxylic acid → 18-[8-Bromo-7-methoxy-2-(thiazol-2-yl)quinolin-4-yloxy]-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-ene-4-carboxylic acid
Reaction equation
[Br:1][c:2]1[c:3]([O:18][CH3:19])[cH:4][cH:5][c:6]2[c:7]([OH:17])[cH:8][c:9](-[c:12]3[s:13][cH:14][cH:15][n:16]3)[n:10][c:11]12.[CH:20]([c:21]1[n:22][c:23](-[c:24]2[cH:25][c:26]([O:27][CH:39]3[CH2:40][N:41]4[C:42](=[O:62])[CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH:49]=[CH:50][CH:51]5[CH2:52][C:53]5([C:59](=[O:60])[OH:61])[NH:54][C:55](=[O:58])[CH:56]4[CH2:57]3)[c:28]3[c:29]([cH:30][c:31]([O:32][CH3:33])[cH:34][cH:35]3)[n:36]2)[s:37][cH:38]1)([CH3:63])[CH3:64]>>[Br:1][c:2]1[c:3]([O:18][CH3:19])[cH:4][cH:5][c:6]2[c:7]([O:17][CH:39]3[CH2:40][N:41]4[C:42](=[O:62])[CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH:49]=[CH:50][CH:51]5[CH2:52][C:53]5([C:59](=[O:60])[OH:61])[NH:54][C:55](=[O:58])[CH:56]4[CH2:57]3)[cH:8][c:9](-[c:12]3[s:13][cH:14][cH:15][n:16]3)[n:10][c:11]12Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-eb00699ba48d427bbe5d17dab1f42529
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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