Dichloromethane → 4-[3-(Trifluoromethyl)-1H-pyrazol-1-yl]cyclohexanol

HRID 815734Notes

Reaction equation

HRID 815734 reaction equation
[C:1]([Si:2]([CH3:3])([CH3:4])[O:6][CH:7]1[CH2:8][CH2:9][CH:10]([n:13]2[n:14][c:15]([C:18]([F:19])([F:20])[F:21])[cH:16][cH:17]2)[CH2:11][CH2:12]1)([CH3:5])([CH3:22])[CH3:23].[CH2:25]([N+:26]([CH2:27][CH2:28][CH2:29][CH3:30])([CH2:31][CH2:32][CH2:33][CH3:34])[CH2:35][CH2:36][CH2:37][CH3:38])[CH2:39][CH2:40][CH3:41].[Cl:42][CH2:43][Cl:44].[F-:24]>>[OH:6][CH:7]1[CH2:8][CH2:9][CH:10]([n:13]2[n:14][c:15]([C:18]([F:19])([F:20])[F:21])[cH:16][cH:17]2)[CH2:11][CH2:12]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 16028TetrabutylammoniumHCID 28179Fluoride IonHCID 595560591-(4-{[tert-Butyl(dimethyl)silyl]oxy}cyclohexyl)-3-(trifluoromethyl)-1H-pyrazole

Product 1

HCID 595561464-[3-(Trifluoromethyl)-1H-pyrazol-1-yl]cyclohexanol

Sources & evidence

ORD record
ord-90bbbf89b76c47d5bd08c6ffcd99c1b1
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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