N-[[18-[2-[4-(isopropyl)thiazol-2-yl]-7-methoxyquinolin-4-yloxy]-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-en-4-yl]carbonyl](cyclopropyl)sulfonamide → N-[17-[2-(4-isopropylthiazol-2-yl)-7-methoxyquinolin-4-yloxy]-2,14-dioxo-3,15-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carbonyl]-(cyclopropyl)sulfonamide
Reaction equation
[CH:1]([c:2]1[n:3][c:4](-[c:5]2[cH:6][c:7]([O:8][CH:9]3[CH2:10][CH:11]4[N:12]([C:13](=[O:14])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH:20]=[CH:21][CH:22]5[C:23]([C:24]([OH:25])=[O:26])([NH:27][C:28]4=[O:29])[CH2:30]5)[CH2:31]3)[c:32]3[c:33]([c:34]([CH3:35])[c:36]([O:37][CH3:38])[cH:39][cH:40]3)[n:41]2)[s:42][cH:43]1)([CH3:44])[CH3:45].[CH:46]([CH3:47])([CH3:48])[c:49]1[n:50][c:51](-[c:54]2[n:55][c:56]3[cH:57][c:58]([O:95][CH3:96])[cH:59][cH:60][c:61]3[c:62]([O:64][CH:65]3[CH2:66][N:67]4[C:68](=[O:94])[CH2:69][CH2:70][CH2:71][CH2:72][CH2:73][CH2:74][CH:75]=[CH:76][CH:77]5[CH2:78][C:79]5([C:85](=[O:86])[NH:87][S:88](=[O:89])(=[O:90])[CH:91]5[CH2:92][CH2:93]5)[NH:80][C:81](=[O:84])[CH:82]4[CH2:83]3)[cH:63]2)[s:52][cH:53]1>>[CH:46]([CH3:47])([CH3:48])[c:49]1[n:50][c:51](-[c:54]2[n:55][c:56]3[cH:57][c:58]([O:95][CH3:96])[cH:59][cH:60][c:61]3[c:62]([O:64][CH:65]3[CH2:66][N:67]4[C:68](=[O:94])[CH2:69][CH2:71][CH2:72][CH2:73][CH2:74][CH:75]=[CH:76][CH:77]5[CH2:78][C:79]5([C:85](=[O:86])[NH:87][S:88](=[O:89])(=[O:90])[CH:91]5[CH2:92][CH2:93]5)[NH:80][C:81](=[O:84])[CH:82]4[CH2:83]3)[cH:63]2)[s:52][cH:53]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-d97d7e8f7bb543d69730041801b2bcaf
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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