N-Methylethylamine → 6-[(5-{2-[ethyl(methyl)amino]ethoxy}pyridin-2-yl)oxy]-N-(1-methyl-1H-pyrazol-3-yl)quinazoline-4-amine
Reaction equation
C(O[CH:4](OCC)[CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]([O:13][C:14]2[CH:15]=[C:16]3[C:21](=[CH:22][CH:23]=2)[N:20]=[CH:19][N:18]=[C:17]3[NH:24][C:25]2[CH:29]=[CH:28][N:27]([CH3:30])[N:26]=2)=[N:11][CH:12]=1)C.[CH2:34]([NH:36][CH3:37])[CH3:35]>>[CH2:34]([N:36]([CH3:37])[CH2:4][CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]([O:13][C:14]2[CH:15]=[C:16]3[C:21](=[CH:22][CH:23]=2)[N:20]=[CH:19][N:18]=[C:17]3[NH:24][C:25]2[CH:29]=[CH:28][N:27]([CH3:30])[N:26]=2)=[N:11][CH:12]=1)[CH3:35]Participants
3
Procedure
Using 6-{[5-(2,2-diethoxyethoxy)pyridin-2-yl]oxy}-N-(1-methyl-1H-pyrazol-3-yl)quinazoline-4-amine obtained in Example 5-1) and ethyl(methyl)amine, and in the same manner as in Example 5-2) and 5-3) or according to a method similar to it or according to a combination thereof with an ordinary method, 6-[(5-{2-[ethyl(methyl)amino]ethoxy}pyridin-2-yl)oxy]-N-(1-methyl-1H-pyrazol-3-yl)quinazoline-4-amine (76 mg) was obtained.
Sources & evidence
- ORD record
- ord-e554d744021d4ab3bef0f01a98d63fd0
- Source dataset
- uspto-grants-2014_09
- Patent number
- US08846700B2
Reaction notes
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