Toluene → 6-isopropyl-N-phenylimidazo[1,2-a]pyridine-2-carboxamide

HRID 816338Notes

Reaction equation

HRID 816338 reaction equation
[CH3:35][c:36]1[cH:37][cH:38][cH:39][cH:40][cH:41]1.[CH3:42][C:43]([CH3:44])([O-:45])[CH3:46].[CH3:48][C:49]([CH3:50])([O-:51])[CH3:52].[CH3:53][C:54]([CH3:55])([O-:56])[CH3:57].[CH3:58][C:59]([CH3:60])([O-:61])[CH3:62].[CH:1]([CH3:2])([CH3:3])[c:4]1[cH:5][cH:6][c:7]2[n:8]([cH:9]1)[cH:10][c:11]([C:13]([O:15][CH2:14][CH3:16])=[O:17])[n:12]2.[NH2:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1.[OH:25][n:26]1[c:27]2[n:28][cH:29][cH:30][cH:31][c:32]2[n:33][n:34]1.[Zr+4:47]>>[CH:1]([CH3:2])([CH3:3])[c:4]1[cH:5][cH:6][c:7]2[n:8]([cH:9]1)[cH:10][c:11]([C:13](=[O:15])[NH:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[n:12]2

Participants

7

Reactant 6

HCID 1140TolueneHCID 6115AnilineHCID 115139Zirconium cation (4+)HCID 181649HOAtHCID 45749132-Methylpropan-2-olate4×HCID 68682228Ethyl 6-isopropylimidazo[1,2-a]pyridine-2-carboxylate

Product 1

HCID 686148456-isopropyl-N-phenylimidazo[1,2-a]pyridine-2-carboxamide

Sources & evidence

ORD record
ord-240e25830e844a8a96e1aa2aea506fc8
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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