4-[(1-Methyl-1H-pyrazol-3-yl)amino]quinazolin-6-ol → 5-chloro-6-({4-[(1-methyl-1H-pyrazol-3-yl)amino]quinazolin-6-yl}oxy)pyridin-3-ol

HRID 81635Notes

Reaction equation

HRID 81635 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([NH:7][C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([OH:18])[CH:16]=3)[N:11]=[CH:10][N:9]=2)=[N:3]1.[Cl:19][C:20]1[C:21](F)=[N:22][CH:23]=[C:24]([O:26]CCC2OCCO2)[CH:25]=1>>[Cl:19][C:20]1[CH:25]=[C:24]([OH:26])[CH:23]=[N:22][C:21]=1[O:18][C:15]1[CH:16]=[C:17]2[C:12](=[CH:13][CH:14]=1)[N:11]=[CH:10][N:9]=[C:8]2[NH:7][C:4]1[CH:5]=[CH:6][N:2]([CH3:1])[N:3]=1

Participants

3

Reactant 2

HCID 231603824-[(1-Methyl-1H-pyrazol-3-yl)amino]quinazolin-6-olHCID 684276893-Chloro-5-[2-(1,3-dioxolan-2-yl)ethoxy]-2-fluoropyridine

Product 1

HCID 684297045-chloro-6-({4-[(1-methyl-1H-pyrazol-3-yl)amino]quinazolin-6-yl}oxy)pyridin-3-ol

Procedure

Using 4-[(1-methyl-1H-pyrazol-3-yl)amino]quinazolin-6-ol and 3-chloro-5-[2-(1,3-dioxolan-2-yl)ethoxy]-2-fluoropyridine, and in the same manner as in Example 6-2) and 6-3) or according to a method similar to it or according to a combination thereof with an ordinary method, 5-chloro-6-({4-[(1-methyl-1H-pyrazol-3-yl)amino]quinazolin-6-yl}oxy)pyridin-3-ol (738 mg) was obtained as a pale yellow amorphous solid.

Sources & evidence

ORD record
ord-718754e5dac24e818ed428102f997f83
Source dataset
uspto-grants-2014_09
Patent number
US08846700B2

Reaction notes

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