Dichloromethane → 4-[3-(4-Chloro-phenyl)-5,6,7,8-tetrahydro-4H-1,2,6-triaza-azulen-1-ylmethyl]-2-fluoro-phenol

HRID 816735Notes

Reaction equation

[B:1]([Br:2])([Br:3])[Br:4].[Cl:32][CH2:33][Cl:34].[Cl:5][c:6]1[cH:7][cH:8][c:9](-[c:12]2[n:13][n:14]([CH2:22][c:23]3[cH:24][c:25]([F:31])[c:26]([O:29][CH3:30])[cH:27][cH:28]3)[c:15]3[c:21]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)[cH:10][cH:11]1>>[Cl:5][c:6]1[cH:7][cH:8][c:9](-[c:12]2[n:13][n:14]([CH2:22][c:23]3[cH:24][c:25]([F:31])[c:26]([OH:29])[cH:27][cH:28]3)[c:15]3[c:21]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)[cH:10][cH:11]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 25134Boron tribromide

HCID 597526763-(4-Chloro-phenyl)-1-(3-fluoro-4-methoxy-benzyl)-1,4,5,6,7,8-hexahydro-1,2,6-triaza-azulene

Product 1

HCID 117490654-[3-(4-Chloro-phenyl)-5,6,7,8-tetrahydro-4H-1,2,6-triaza-azulen-1-ylmethyl]-2-fluoro-phenol

Sources & evidence

ORD record: ord-f618661692284d78b3171de2d506f2e9
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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