tert-Butyl acetate → 3-[3-(2-Methyl-imidazol-1-yl)-phenyl]-3-oxo-propionic acid tert.-butyl ester

HRID 816824Notes

Reaction equation

HRID 816824 reaction equation
[C:18]([CH3:19])(=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25].[CH3:1][c:2]1[n:3](-[c:7]2[cH:8][c:9]([C:10]([O:12][CH2:11][CH3:13])=[O:14])[cH:15][cH:16][cH:17]2)[cH:4][cH:5][n:6]1.[Li:26]>>[CH3:1][c:2]1[n:3](-[c:7]2[cH:8][c:9]([C:10](=[O:12])[CH2:19][C:18](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[cH:15][cH:16][cH:17]2)[cH:4][cH:5][n:6]1

Participants

4

Reactant 3

HCID 10908tert-Butyl acetateHCID 3028194LithiumHCID 22224621Ethyl 3-(2-methyl-imidazol-1-yl)-benzoate

Product 1

HCID 695927863-[3-(2-Methyl-imidazol-1-yl)-phenyl]-3-oxo-propionic acid tert.-butyl ester

Sources & evidence

ORD record
ord-da417da39b194ab48c36bd2179f99fd8
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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