Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Methoxyethyl chloroformate → 3-(4-(3(S)-(2-Methoxyethoxycarbonylamino)pyrrolidin-1-yl)-3-fluorophenyl)-5(S)-(isoxazol-3-ylaminomethyl)oxazolidin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Methoxyethyl chloroformate | HCID 69400 | — |
| 반응물 | Oxazolidin-2-one hydrochloride salt | HCID 19037880 | — |
| 반응물 | 5(S)-Isoxazol-3-ylaminomethyl-3-(4-(3(S)-acetamidopyrrolidin-1-yl)-3-fluorophenyl)oxazolidin-2-one | HCID 20725710 | — |
| 생성물 | 3-(4-(3(S)-(2-Methoxyethoxycarbonylamino)pyrrolidin-1-yl)-3-fluorophenyl)-5(S)-(isoxazol-3-ylaminomethyl)oxazolidin-2-one | HCID 69584876 | — |
반응 단계
Using essentially the method for the intermediate of Example 12, starting from 3-(4(3(S)-aminopyrrolidin-1-yl)-3-fluorophenyl)-5(R)-(N-2,2,2-trichloroethyloxycarbonyl)isoxazol-3-ylaminomethyl)oxazolidin-2-one hydrochloride salt (419 mg, 0.73 mM) and 2-methoxyethyl chloroformate (450 mg, 3.27 mM) gave the title compound (442 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07087629B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-23028e4a040e4c08b0b8bcec767ce4a0 |
| 출처 메모 | uspto-grants-2006_08 |