2-(Bromomethyl)tetrahydro-2H-pyran → tert-butyl 4-[(5,6-difluoro-2'-oxospiro[1-benzofuran-3,3-indol]-1'(2'H)-yl)methyl]piperidine-1-carboxylate

HRID 816993Notes

Reaction equation

HRID 816993 reaction equation
[Br:26][CH2:27][CH:28]1[CH2:29][CH2:30][CH2:31][CH2:32][O:33]1.[F:34][c:35]1[c:36]([F:53])[cH:37][c:38]2[c:39]([cH:52]1)[C:40]1([CH2:41][O:42]2)[C:43](=[O:51])[NH:44][c:45]2[cH:46][cH:47][cH:48][cH:49][c:50]21.[S:1]([O:2][CH2:12][CH:13]1[CH2:14][CH2:15][N:16]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:17][CH2:18]1)([c:3]1[cH:4][cH:5][c:6]([CH3:7])[cH:8][cH:9]1)(=[O:10])=[O:11]>>[CH2:12]([CH:13]1[CH2:14][CH2:15][N:16]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:17][CH2:18]1)[N:44]1[C:43](=[O:51])[C:40]2([c:39]3[c:38]([cH:37][c:36]([F:53])[c:35]([F:34])[cH:52]3)[O:42][CH2:41]2)[c:50]2[c:45]1[cH:46][cH:47][cH:48][cH:49]2

Participants

4

Reactant 3

HCID 1419172-(Bromomethyl)tetrahydro-2H-pyranHCID 106428511-(tert-Butoxycarbonyl)-4-((p-toluenesulfonyloxy)methyl)piperidineHCID 593525695,6-difluorospiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

Product 1

HCID 59352356tert-butyl 4-[(5,6-difluoro-2'-oxospiro[1-benzofuran-3,3-indol]-1'(2'H)-yl)methyl]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-f947012434fc4d0ab973d584006206d4
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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