HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenamine, 4-(4-morpholinyl)- → (E)-N-(3-(2-(4-morpholinophenylamino)pyrimidin-4-ylthio)phenyl)but-2-enamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenamine, 4-(4-morpholinyl)- | HCID 75655 | — |
| Reactant | (E)-N-(3-(2-chloropyrimidin-4-ylthio)phenyl)but-2-enamide | HCID 86645570 | — |
| Product | (E)-N-(3-(2-(4-morpholinophenylamino)pyrimidin-4-ylthio)phenyl)but-2-enamide | HCID 59491799 | 69.6% |
Reaction Steps
In a procedure analogous to Example 8, reaction of (E)-N-(3-(2-chloropyrimidin-4-ylthio)phenyl)but-2-enamide (103 mg, 0.26 mmol) and 4-morpholinoaniline (47 mg, 0. 26 mmol) furnished the product (81 mg, 69%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846704B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-dcdee2642e314ceabf4d9cee060e0563 |
| Source note | uspto-grants-2014_09 |