7-amino-1-methyl-4,5-dihydro-3,1-benzoxazepin-2(1H)-one → 2-{5-Chloro-4-[2-(5-methyl-[1,3,4]thiadiazol-2-yl)-phenylamino]-pyrimidin-2-ylamino}-5-methyl-8,9-dihydro-5H-7-oxa-5-aza-benzocyclohepten-6-one

HRID 817251Notes

Reaction equation

HRID 817251 reaction equation
[Cl:1][c:2]1[n:3][cH:4][c:5]([Cl:21])[c:6]([NH:8][c:9]2[c:10](-[c:15]3[s:16][c:17]([CH3:20])[n:18][n:19]3)[cH:11][cH:12][cH:13][cH:14]2)[n:7]1.[NH2:22][c:23]1[cH:24][cH:25][c:26]2[c:27]([cH:35]1)[CH2:28][CH2:29][O:30][C:31](=[O:34])[N:32]2[CH3:33]>>[c:2]1([NH:22][c:23]2[cH:24][cH:25][c:26]3[c:27]([cH:35]2)[CH2:28][CH2:29][O:30][C:31](=[O:34])[N:32]3[CH3:33])[n:3][cH:4][c:5]([Cl:21])[c:6]([NH:8][c:9]2[c:10](-[c:15]3[s:16][c:17]([CH3:20])[n:18][n:19]3)[cH:11][cH:12][cH:13][cH:14]2)[n:7]1

Participants

3

Reactant 2

HCID 580154687-amino-1-methyl-4,5-dihydro-3,1-benzoxazepin-2(1H)-oneHCID 86634053(2,5-Dichloro-pyrimidin-4-yl)-[2-(5-methyl-[1,3,4]thiadiazol-2-yl)-phenyl]-amine

Product 1

HCID 668304082-{5-Chloro-4-[2-(5-methyl-[1,3,4]thiadiazol-2-yl)-phenylamino]-pyrimidin-2-ylamino}-5-methyl-8,9-dihydro-5H-7-oxa-5-aza-benzocyclohepten-6-one

Sources & evidence

ORD record
ord-c5dd90f8e0ec47ce99e45573cbc25f16
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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