Acrylic Acid → HCID 59491748, compound

HRID 81726Notes

Reaction equation

HRID 81726 reaction equation
[NH2:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9][C:10]2[CH:15]=[CH:14][N:13]=[C:12]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH2:28][CH2:27][O:26][CH2:25][CH2:24]4)=[CH:19][CH:18]=3)[N:11]=2)=[CH:5][CH:4]=1.[C:29](O)(=[O:32])[CH:30]=[CH2:31]>>[O:26]1[CH2:25][CH2:24][N:23]([C:20]2[CH:21]=[CH:22][C:17]([NH:16][C:12]3[N:11]=[C:10]([S:9][C:6]4[CH:5]=[CH:4][C:3]([CH2:2][NH:1][C:29](=[O:32])[CH:30]=[CH2:31])=[CH:8][CH:7]=4)[CH:15]=[CH:14][N:13]=3)=[CH:18][CH:19]=2)[CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 6581Acrylic AcidHCID 59491476HCID 59491476, compound

Product 1

HCID 59491748HCID 59491748, compoundYield 27.3%

Procedure

In a procedure analogous to Example 15, reaction of 4-(4-(aminomethyl)phenylthio)-N-(4-morpholinophenyl)pyrimidin-2-amine (70 mg, 0.18 mmol) and acrylic acid (19 mg, 0.27 mmol) furnished the product (22 mg, 27%).

Sources & evidence

ORD record
ord-f82310af90fa41fdad4b832b1794cd80
Source dataset
uspto-grants-2014_09
Patent number
US08846704B2

Reaction notes

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