3-Chloro-4-fluoroaniline → 2-(3 Chloro-4-fluorophenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclohexylmethyl-amide
Reaction equation
[CH:1]1([CH2:7][NH:8][C:9](=[O:10])[c:11]2[c:12]([C:18]([F:19])([F:20])[F:21])[n:13][c:14]([Cl:17])[n:15][cH:16]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1.[Cl:22][c:23]1[cH:24][c:25]([NH2:26])[cH:27][cH:28][c:29]1[F:30].[O:31]1[CH2:32][CH2:33][O:34][CH2:35][CH2:36]1>>[CH:1]1([CH2:7][NH:8][C:9](=[O:10])[c:11]2[c:12]([C:18]([F:19])([F:20])[F:21])[n:13][c:14]([NH:26][c:25]3[cH:24][c:23]([Cl:22])[c:29]([F:30])[cH:28][cH:27]3)[n:15][cH:16]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1Participants
4
Sources & evidence
- ORD record
- ord-d6894dfc71a24c129bbabefb0e6ac33d
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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