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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 817419Generated: October 26, 2026

Ammonium → 3-{1-[Bis(4-chlorophenyl)methyl]azetidin-3-yl}-3-(3,5-difluorophenyl)-3-hydroxy-2,2-dimethylpropanenitrile

https://huagongshe.com/reaction/817419

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAmmoniumHCID 223—
ReactantChlorideHCID 312—
ReactantIsobutyronitrileHCID 6559—
ReactantTetrahydrofuranHCID 8028—
Reactant{1-[Bis(4-chlorophenyl)methyl]azetidin-3-yl}(3,5-difluorophenyl)methanoneHCID 22506671—
ReactantButyllithiumHCID 178418339—
Product3-{1-[Bis(4-chlorophenyl)methyl]azetidin-3-yl}-3-(3,5-difluorophenyl)-3-hydroxy-2,2-dimethylpropanenitrileHCID 67065873—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTest data from https://doi.org/10.1039/C8SC04228D
ORD IDord-845cb7130afd405aa7053e08fc68cb60
Source noteTest data from https://doi.org/10.1039/C8SC04228D