Pyridine → N-[5-(3-{[3-(1-cyano-1-methylethyl)benzoyl]amino}-4-methylphenoxy)[1,3]thiazolo[5,4-b]pyridin-2-yl]-1,3-oxazole-4-carboxamide

HRID 817626Notes

Reaction equation

HRID 817626 reaction equation
[NH2:9][c:10]1[s:11][c:12]2[n:13][c:14]([O:19][c:20]3[cH:21][cH:22][c:23]([CH3:40])[c:24]([NH:26][C:27]([c:28]4[cH:29][c:30]([C:34]([CH3:35])([CH3:36])[C:37]#[N:38])[cH:31][cH:32][cH:33]4)=[O:39])[cH:25]3)[cH:15][cH:16][c:17]2[n:18]1.[cH:41]1[cH:42][cH:43][n:44][cH:45][cH:46]1.[o:1]1[cH:2][n:3][c:4]([C:6](=[O:7])[Cl:8])[cH:5]1>>[o:1]1[cH:2][n:3][c:4]([C:6](=[O:7])[NH:9][c:10]2[s:11][c:12]3[n:13][c:14]([O:19][c:20]4[cH:21][cH:22][c:23]([CH3:40])[c:24]([NH:26][C:27]([c:28]5[cH:29][c:30]([C:34]([CH3:35])([CH3:36])[C:37]#[N:38])[cH:31][cH:32][cH:33]5)=[O:39])[cH:25]4)[cH:15][cH:16][c:17]3[n:18]2)[cH:5]1

Participants

4

Reactant 3

HCID 1049PyridineHCID 142814311,3-Oxazole-4-carbonyl chlorideHCID 86646000N-{5-[(2-amino[1,3]thiazolo[5,4-b]pyridin-5-yl)oxy]-2-methylphenyl}-3-(1-cyano-1-methylethyl)benzamide

Product 1

HCID 59507036N-[5-(3-{[3-(1-cyano-1-methylethyl)benzoyl]amino}-4-methylphenoxy)[1,3]thiazolo[5,4-b]pyridin-2-yl]-1,3-oxazole-4-carboxamide

Sources & evidence

ORD record
ord-a1c6b1ab1fca423f9bf34e48d461bac8
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…