反应详情

To a solution of 5-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-isopropyl-4-methoxy-phenoxy]-pyrimidine-2,4-diamine (0.033 g, 0.096 mmol) in dry methylene chloride (25 ml) was added barium manganate (0.4 g, 1.56 mmol). The reaction mixture refluxed over night, after which more of barium manganate (0.1 g) was added, and the mixture was refluxed for another 6 hours. The reaction mixture was filtered through celite, and the filtrate was concentrated under reduced pressure. The residue was purified with preparative TLC (8% methanol in methylene chloride/0.1% concentrated ammonium hydroxide) to yield 5-[5-(1H-imidazol-2-yl)-2-isopropyl-4-methoxy-phenoxy]-pyrimidine-2,4-diamine as pale yellow solid (0.026 g, 41%).

1. temperatureThe reaction mixture refluxed over night
2. temperaturethe mixture was refluxed for another 6 hours
3. filtrationThe reaction mixture was filtered through celite
4. concentrationthe filtrate was concentrated under reduced pressure
5. customThe residue was purified with preparative TLC (8% methanol in methylene chloride/0.1% concentrated ammonium hydroxide)