(2-Amino-5-pyrrolidin-1-yl-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester → {2-[3-(2-Cyano-pyridin-4-yl)-3-oxo-propionylamino]-5-pyrrolidin-1-yl-4-trifluoromethyl-phenyl}-carbamic acid tert.-butyl ester
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][c:8]1[c:9]([NH2:23])[cH:10][c:11]([C:19]([F:20])([F:21])[F:22])[c:12]([N:14]2[CH2:15][CH2:16][CH2:17][CH2:18]2)[cH:13]1)=[O:24].[C:25]([CH3:27])([CH3:28])([O:29][C:30](=[O:26])[CH2:31][C:32](=[O:33])[c:34]1[cH:35][c:36]([C:40]#[N:41])[n:37][cH:38][cH:39]1)[CH3:42]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][c:8]1[c:9]([NH:23][C:30](=[O:29])[CH2:31][C:32](=[O:33])[c:34]2[cH:35][c:36]([C:40]#[N:41])[n:37][cH:38][cH:39]2)[cH:10][c:11]([C:19]([F:20])([F:21])[F:22])[c:12]([N:14]2[CH2:15][CH2:16][CH2:17][CH2:18]2)[cH:13]1)=[O:24]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-39714444204446bea6778bcd3d47e22e
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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