Acetonitrile → (8-Bromo-5-ethyl-2,3-dihydro-benzo[1,4]dioxin-6-yloxy)-acetonitrile

HRID 81797Notes

Reaction equation

HRID 81797 reaction equation
[Br:1][C:2]1[C:7]2[O:8][CH2:9][CH2:10][O:11][C:6]=2[C:5]([CH2:12][CH3:13])=[C:4]([OH:14])[CH:3]=1.[C:15](#[N:17])[CH3:16]>>[Br:1][C:2]1[C:7]2[O:8][CH2:9][CH2:10][O:11][C:6]=2[C:5]([CH2:12][CH3:13])=[C:4]([O:14][CH2:16][C:15]#[N:17])[CH:3]=1

Participants

3

Reactant 2

HCID 6342AcetonitrileHCID 595985418-Bromo-5-ethyl-2,3-dihydro-benzo[1,4]dioxin-6-ol

Product 1

HCID 59598681(8-Bromo-5-ethyl-2,3-dihydro-benzo[1,4]dioxin-6-yloxy)-acetonitrile

Procedure

8-Bromo-5-ethyl-2,3-dihydro-benzo[1,4]dioxin-6-ol (3.182 g, 12.3 mmol), as described in the procedure of Step 6 of Example 21, was converted to cyanomethyl ether 8-Bromo-5-ethyl-2,3-dihydro-benzo[1,4]dioxin-6-yloxy)-acetonitrile (2.30 g, 63%).

Sources & evidence

ORD record
ord-759d7c0d33f140cf82262b0789f7ea9c
Source dataset
uspto-grants-2014_09
Patent number
US08846705B2

Reaction notes

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