反应详情

Di-(t-butoxycarbonyl)aminopyrazine (2.1 g, 7.1 mM) in methanol (50 ml) under nitrogen, was treated with aqueous sodium hydroxide (2.5 M, 2.84 ml, 7.1 mM), and stirred at ambient temperature for 2 hours. The mixture was neutralised by the addition of water (25 ml) and solid carbon dioxide, then methanol evaporated. The residual aqueous solution was extracted with dichloromethane (2×20 ml), the extracts washed with brine (20 ml) and evaporated. The resulting solid was triturated with isohexane (50 ml) to give the title product as a white solid (1.03 g).

1. custommethanol evaporated
2. extractionThe residual aqueous solution was extracted with dichloromethane (2×20 ml)
3. washthe extracts washed with brine (20 ml)
4. customevaporated
5. customThe resulting solid was triturated with isohexane (50 ml)