ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate → Ethyl 6-({3-(aminocarbonyl)-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}amino)imidazo[1,2-b]pyridazine-2-carboxylate
Reaction equation
[Cl:1][c:2]1[cH:3][cH:4][c:5]2[n:6]([n:7]1)[cH:8][c:9]([C:11](=[O:12])[O:13][CH2:14][CH3:15])[n:10]2.[NH2:16][c:17]1[s:18][c:19](-[c:25]2[c:26]([F:36])[cH:27][c:28]([C:32]([CH3:33])([CH3:34])[OH:35])[cH:29][c:30]2[F:31])[cH:20][c:21]1[C:22](=[O:23])[NH2:24]>>[c:2]1([NH:16][c:17]2[s:18][c:19](-[c:25]3[c:26]([F:36])[cH:27][c:28]([C:32]([CH3:33])([CH3:34])[OH:35])[cH:29][c:30]3[F:31])[cH:20][c:21]2[C:22](=[O:23])[NH2:24])[cH:3][cH:4][c:5]2[n:6]([n:7]1)[cH:8][c:9]([C:11](=[O:12])[O:13][CH2:14][CH3:15])[n:10]2Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-c209ae970f56459fa4c6348583fe1ada
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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