4'-Bromo-[1,1'-biphenyl]-4-carbaldehyde → HCID 86694676, compound

Participants

Reaction Steps

Primary aniline 1 was coupled to 4′-bromo-[1,1′-biphenyl]-4-carbaldehyde on a 3.7 mmol scale via General Procedure A to furnish 5 (1.52 g, 70%): δH (400 MHz, CDCl3) 4.39 (s, 2H, CH2), 4.59 (br s, 1H, NH), 5.10 (s, 2H, CH2), 5.31 (s, 2H, CH2), 6.20 (d, J=2.0 Hz, 1H, CH), 6.24 (d of d, J=8.6 and 2.0 Hz, 1H, CH), 7.25-7.36 (m, 6H, CH), 7.37-7.49 (m, 8H, CH), 7.53 (d, J=8.4 Hz, 2H, CH), 7.57 (d, J=8.4 Hz, 2H, CH) 7.85 (d, J=8.6 Hz, 1H, CH); δC (100 MHz, CDCl3) 47.3, 65.7, 70.3, 97.4, 104.9, 108.7, 121.5, 126.8, 127.1, 127.5, 127.6, 127.8, 127.9, 128.3, 128.3, 128.5, 131.8, 134.3, 136.6, 136.7, 137.6, 139.1, 139.4, 152.6, 160.8, 165.6.

Provenance & Evidence