Methanol → tert-Butyl 4-(1-hydroxyethyl)piperidine-1-carboxylate

HRID 818679Notes

Reaction equation

HRID 818679 reaction equation
[BH4-:17].[C:1]([CH3:2])(=[O:3])[CH:4]1[CH2:5][CH2:6][N:7]([C:10](=[O:11])[O:12][C:13]([CH3:14])([CH3:15])[CH3:16])[CH2:8][CH2:9]1.[CH3:19][OH:20].[Na+:18]>>[CH:1]([CH3:2])([OH:3])[CH:4]1[CH2:5][CH2:6][N:7]([C:10](=[O:11])[O:12][C:13]([CH3:14])([CH3:15])[CH3:16])[CH2:8][CH2:9]1

Participants

5

Reactant 4

HCID 887MethanolHCID 923Sodium ionHCID 28123BorohydrideHCID 109879834-Acetyl-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 21989903tert-Butyl 4-(1-hydroxyethyl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-9a2be5936e79428fbb4b522159454507
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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