Bromide ion → 6-chloro-4-(2-fluorophenyl)-3-(2,2,2-trifluoroethyl)-4-(trifluoromethyl)-1H-quinazolin-2-one

HRID 819343Notes

Reaction equation

HRID 819343 reaction equation
[Br-:50].[Cl:1][c:2]1[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[NH:8][C:7](=[O:12])[N:6]([CH2:13][C:14]([F:15])([F:16])[F:17])[C:5]2([C:18]([F:19])([F:20])[F:21])[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1.[Cl:28][c:29]1[cH:30][c:31]2[c:32]([cH:33][cH:34]1)[NH:35][C:36](=[O:37])[N:38]([CH2:39][C:40]([F:41])([F:42])[F:43])[C:44]2([OH:45])[C:46]([F:47])([F:48])[F:49].[F:51][c:52]1[cH:53][cH:54][c:55]([Mg+:56])[cH:57][cH:58]1>>[Cl:1][c:2]1[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[NH:8][C:7](=[O:12])[N:6]([CH2:13][C:14]([F:15])([F:16])[F:17])[C:5]2([C:18]([F:19])([F:20])[F:21])[c:22]1[c:23]([F:42])[cH:24][cH:25][cH:26][cH:27]1

Participants

5

Reactant 4

HCID 259Bromide ionHCID 118540726-chloro-4-phenyl-3-(2,2,2-trifluoroethyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-oneHCID 593466016-Chloro-4-hydroxy-3-(2,2,2-trifluoroethyl)-4-(trifluoromethyl)-3,4-dihydro-quinazolin-2(1H)-oneHCID 178505839HCID 178505839, compound

Product 1

HCID 118540736-chloro-4-(2-fluorophenyl)-3-(2,2,2-trifluoroethyl)-4-(trifluoromethyl)-1H-quinazolin-2-one

Sources & evidence

ORD record
ord-de79e4f14ec348a0b2214d856168d6ea
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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