反应详情

2-[2-(Benzyloxy)ethyl]-1-(2-fluoro-2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridine (1.89 g, 5.0 mmol) was dissolved in 50 mL of CH2Cl2 and treated with 3-chloroperoxybenzoic acid (1.50 g, 57-86% purity). After stirring for 2 hours, the reaction mixture was treated with 50 mL of 2% Na2CO3 solution and the layers were separated. The aqueous portion was extracted with an additional 25 mL of CH2Cl2. The combined organic layers were washed successively with 2% Na2CO3, H2O and brine, dried over Na2SO4, filtered, and concentrated under reduced pressure to give 1.97 g of 2-[2-(benzyloxy)ethyl]-1-(2-fluoro-2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridine 5-oxide as an off-white solid.

1. customthe layers were separated
2. extractionThe aqueous portion was extracted with an additional 25 mL of CH2Cl2
3. washThe combined organic layers were washed successively with 2% Na2CO3, H2O and brine
4. dry with materialdried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure