4-(4-Amino-2-fluoro-phenoxy)-6,7-dimethoxy-quinolin-2-ylamine → N-(4-{[2-amino-6,7-bis(methyloxy)quinolin-4-yl]oxy}-3-fluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
Reaction equation
[CH3:25][O:26][c:27]1[cH:28][c:29]2[c:30]([cH:31][c:32]1[O:33][CH3:34])[n:35][c:36]([S:37][CH3:38])[cH:39][c:40]2[O:41][c:42]1[cH:43][cH:44][c:45]([NH:46][C:49](=[O:50])[C:51]2([C:54](=[O:55])[NH:56][c:57]3[cH:58][cH:59][c:60]([F:63])[cH:61][cH:62]3)[CH2:52][CH2:53]2)[cH:47][c:48]1[F:64].[NH2:1][c:2]1[cH:3][c:4]([F:24])[c:5]([O:6][c:7]2[cH:8][c:9]([NH2:21])[n:10][c:11]3[cH:12][c:13]([O:19][CH3:20])[c:14]([O:17][CH3:18])[cH:15][c:16]23)[cH:22][cH:23]1>>[NH:1]([c:2]1[cH:3][c:4]([F:24])[c:5]([O:6][c:7]2[cH:8][c:9]([NH2:21])[n:10][c:11]3[cH:12][c:13]([O:19][CH3:20])[c:14]([O:17][CH3:18])[cH:15][c:16]23)[cH:22][cH:23]1)[C:49](=[O:50])[C:51]1([C:54](=[O:55])[NH:56][c:57]2[cH:58][cH:59][c:60]([F:63])[cH:61][cH:62]2)[CH2:52][CH2:53]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-1e2d5bd362d945629815a4b5eb757fa9
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
Loading…