HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 81945Generated: October 25, 2026
Water → Ethyl 8-amino-1-methyl-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate
https://huagongshe.com/reaction/81945
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Carbonic acid-guanidine (1:1) | HCID 286947 | — |
| Reactant | ethyl 6-[(dimethylamino)methylene]-1-methyl-7-oxo-4,5,6,7-tetrahydro-1H-indazole-3-carboxylate | HCID 67075650 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ethyl 8-amino-1-methyl-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate | HCID 57444093 | 164.8% |
Reaction Steps
To a solution of 16.62 g (60 mmol) of ethyl 6-[(dimethylamino)methylene]-7-oxo-1-methyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxylate in 0.5 L of DMF, 27 g (150 mmol) of guanidine carbonate was added. The mixture was stirred at 110° C. overnight. After cooling the mixture was poured into water (2.5 L) and stirred for 30 minutes. The precipitate was filtered, washed with water and dried to yield 26.83 g of title compound (91%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08846701B2 |
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| Source dataset | uspto-grants-2014_09 |
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| ORD ID | ord-144ba9531d5744d5aa961aa3f4d7ebf8 |
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| Source note | uspto-grants-2014_09 |
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