反应详情

Ethyl 8-amino-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate (275 mg, 1 mmol) was to suspended in anhydrous ethanol (10 mL) and treated with a 2 M solution of sodium hydroxide (0.5 mL, 1 eq.) at reflux temperature for 1 hour. Solvent was evaporated to dryness and the residue dissolved in water. After treatment with acetic acid and the resulting precipitate was collected by filtration to give the title compound (180 mg, 74% yield) as a white solid.

1. temperatureat reflux temperature for 1 hour
2. customSolvent was evaporated to dryness
3. dissolutionthe residue dissolved in water
4. filtrationAfter treatment with acetic acid and the resulting precipitate was collected by filtration