Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 81960생성일: 2026년 10월 26일
Methylamine → N-(2,6-Diethylphenyl)-1-methyl-8-{[1-(N-methyl-beta-alanyl)piperidin-4-yl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide
https://huagongshe.com/reaction/81960
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methylamine | HCID 6329 | — |
| 반응물 | 8-[(1-Acryloylpiperidin-4-yl)amino]-N-(2,6-diethylphenyl)-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | HCID 44555972 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Ammonium Hydroxide | HCID 14923 | — |
| 용매 | Dichloromethane methanol | HCID 21226129 | — |
| 생성물 | N-(2,6-Diethylphenyl)-1-methyl-8-{[1-(N-methyl-beta-alanyl)piperidin-4-yl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | HCID 67075688 | 77% |
반응 단계
To a solution 8-[(1-acryloylpiperidin-4-yl)amino]-N-(2,6-diethylphenyl)-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (30 mg, 0.058 mmol) in tetrahydrofurane (1 mL) in a sealed tube, methylamine (2M in tetrahydrofurane) (0.3 mL) was added. The mixture was then heated at 60° C. for 2 h. Solvent evaporated to dryness and the crude solid was purified by flash chromatography on silica gel (eluant: dichloromethane/methanol/30% ammonium hydroxide: 8/2/0.2) to 27 mg of the title compound (77% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08846701B2 |
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| 출처 데이터셋 | uspto-grants-2014_09 |
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| ORD ID | ord-96b81676cf56401caecc340ebc3b17df |
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| 출처 메모 | uspto-grants-2014_09 |
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