反应详情

温度

100 °C

To a suspension of N-(2,6-diethylphenyl)-8-[(2-methoxy-4-nitrophenyl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (1.4 g, 2.656 mmol) in 27 ml of dioxane, zinc (695 mg, 10.624 mmol) and ammonium chloride (1.4 g, 26.56 mmol) in 2.7 ml of water were added and heated at 100° C. under stirring for 8 h. The mixture was cooled, the insoluble material filtered off and washed with ethyl acetate, the combined organic solutions are washed with aqueous citric acid solution, dried on Na2SO4 and evaporated in vacuo leaving a pink foam as crude title product that has been used without any further purification.

1. additionwere added
2. temperatureThe mixture was cooled
3. filtrationthe insoluble material filtered off
4. washwashed with ethyl acetate
5. washthe combined organic solutions are washed with aqueous citric acid solution
6. customdried on Na2SO4
7. customevaporated in vacuo