4-Acetoxy-3-phenyl-butyric Acid Methyl Ester → Dihydro-4-phenylfuran-2(3H)-one

Participants

Reaction Conditions

Reaction Steps

A solution of 4-acetoxy-3-phenyl-butyric acid methyl ester, (4.5 g, 19.2 mmol) in 1,4-dioxane (29 mL) and sulfuric acid (29 mL) is stirred at room temperature for one hour then heated at 45° C. for 18 h. Volatile solvents are evaporated and the residue is extracted with toluene. The combined organic extracts are extracted with water and brine, filtered, and concentrated to yield the title compound, 2.2 g (71%), as a colorless liquid.

Provenance & Evidence