Cyanogen Bromide → HCID 66571282, compound

HRID 81997Notes

Reaction equation

HRID 81997 reaction equation
[CH3:1][C:2]1[C:6]([C:7]2[CH:16]=[C:15]3[C:10]([C:11]([NH:18][CH2:19][C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=4)=[C:12]([NH2:17])[CH:13]=[N:14]3)=[CH:9][C:8]=2[O:26][CH3:27])=[C:5]([CH3:28])[O:4][N:3]=1.[N:29]#[C:30]Br>>[CH3:1][C:2]1[C:6]([C:7]2[C:8]([O:26][CH3:27])=[CH:9][C:10]3[C:11]4[N:18]([CH2:19][C:20]5[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=5)[C:30]([NH2:29])=[N:17][C:12]=4[CH:13]=[N:14][C:15]=3[CH:16]=2)=[C:5]([CH3:28])[O:4][N:3]=1

Participants

3

Reactant 2

HCID 10476Cyanogen BromideHCID 672071317-(3,5-dimethyl-4-isoxazolyl)-6-(methoxy)-N4-(2-pyridinylmethyl)-3,4-quinolinediamine

Product 1

HCID 66571282HCID 66571282, compoundYield 32%

Procedure

From 7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-N4-(2-pyridinylmethyl)-3,4-quinolinediamine (for a preparation see Intermediate 17) (35 mg) and cyanogen bromide (10 mg) to give the title compound as beige solid (12 mg, 32%). LCMS (formate) Rt 0.61 min, MH+ 401

Sources & evidence

ORD record
ord-9752e2254bf34be69f7ed8395993d3ca
Source dataset
uspto-grants-2014_09
Patent number
US08846709B2

Reaction notes

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