HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ethyl isothiocyanate → 7-(3,5-dimethyl-4-isoxazolyl)-N-ethyl-1-[1-methyl-2-(methyloxy)ethyl]-8-(methyloxy)-1H-imidazo[4,5-c]quinolin-2-amine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Ethyl isothiocyanate | HCID 10966 | — |
| Edukt | 7-(3,5-dimethylisoxazol-4-yl)-6-methoxy-N4-(1-methoxypropan-2-yl)quinoline-3,4-diamine | HCID 70980379 | — |
| Produkt | 7-(3,5-dimethyl-4-isoxazolyl)-N-ethyl-1-[1-methyl-2-(methyloxy)ethyl]-8-(methyloxy)-1H-imidazo[4,5-c]quinolin-2-amine | HCID 66571285 | 52% |
Reaktionsschritte
From 7-(3,5-dimethylisoxazol-4-yl)-6-methoxy-N4-(1-methoxypropan-2-yl)quinoline-3,4-diamine (for a preparation see Intermediate 17) (70 mg) and isothiocyanatoethane (50 mg) to give the title compound as beige solid (42 mg, 52%). LCMS (formate) Rt 0.78 min, MH+ 410
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08846709B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-5305a2f38a9f48558823f25e0a2c503d |
| Quellennotiz | uspto-grants-2014_09 |