反应详情

A solution of 5-methoxyanthranilic acid (Lancaster) (41.8 g, 0.25 mol) was refluxed in acetic anhydride (230 ml) for 3.5 h before being concentrated under reduced pressure. The crude compound was then concentrated twice in the presence of toluene before being filtered and washed twice with ether to yield to the title compound (33.7 g, 71% yield) as a brown solid; LC/MS (Method D): m/z 192 [M+H]+, Rt 1.69 min.

1. concentrationbefore being concentrated under reduced pressure
2. concentrationThe crude compound was then concentrated twice in the presence of toluene
3. filtrationbefore being filtered
4. washwashed twice with ether