5-bromo-N-(2-(dimethylamino)ethyl)thiophene-2-sulfonamide → 5-[5-(4-Chloro-3-methyl-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-thiophene-2-sulfonic acid (2-dimethylamino-ethyl)-amide

HRID 820362Notes

Reaction equation

HRID 820362 reaction equation
[CH3:24][N:25]([CH2:26][CH2:27][NH:28][S:29](=[O:30])(=[O:31])[c:32]1[s:33][c:34]([Br:37])[cH:35][cH:36]1)[CH3:38].[Cl:1][c:2]1[c:3]([CH3:23])[cH:4][c:5](-[c:8]2[n:9][c:10]3[n:11]([c:12]([C:14]([F:15])([F:16])[F:17])[cH:13]2)[n:18][cH:19][c:20]3[C:21]#[CH:22])[cH:6][cH:7]1>>[Cl:1][c:2]1[c:3]([CH3:23])[cH:4][c:5](-[c:8]2[n:9][c:10]3[n:11]([c:12]([C:14]([F:15])([F:16])[F:17])[cH:13]2)[n:18][cH:19][c:20]3[C:21]#[C:22][c:34]2[s:33][c:32]([S:29]([NH:28][CH2:27][CH2:26][N:25]([CH3:24])[CH3:38])(=[O:30])=[O:31])[cH:36][cH:35]2)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 87167995-bromo-N-(2-(dimethylamino)ethyl)thiophene-2-sulfonamideHCID 866080535-(4-Chloro-3-methyl-phenyl)-3-ethynyl-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine

Product 1

HCID 670007245-[5-(4-Chloro-3-methyl-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-thiophene-2-sulfonic acid (2-dimethylamino-ethyl)-amide

Sources & evidence

ORD record
ord-cdcd1bfe5aae4848a8480ae443850394
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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