1,1,1-Trifluoro-2-(4-iodo-phenyl)-propan-2-ol → 8-(Cyclopropylsulfonyl)-2-(4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)-2,8-diazaspiro[4.5]decan-1-one
Reaction equation
[CH:18]1([S:19]([N:20]2[CH2:21][CH2:22][C:23]3([C:24](=[O:25])[N:26]([c:27]4[cH:28][cH:29][c:30]([CH:31]([OH:32])[C:33]([F:34])([F:35])[F:36])[cH:37][cH:38]4)[CH2:39][CH2:40]3)[CH2:41][CH2:42]2)(=[O:43])=[O:44])[CH2:45][CH2:46]1.[CH:1]1([S:4](=[O:5])(=[O:6])[N:7]2[CH2:8][CH2:9][C:10]3([CH2:11][CH2:12][NH:13][C:14]3=[O:15])[CH2:16][CH2:17]2)[CH2:2][CH2:3]1.[F:47][C:48]([C:49]([CH3:50])([OH:51])[c:52]1[cH:53][cH:54][c:55]([I:58])[cH:56][cH:57]1)([F:59])[F:60]>>[CH:1]1([S:4](=[O:5])(=[O:6])[N:7]2[CH2:8][CH2:9][C:10]3([CH2:11][CH2:12][N:13]([c:55]4[cH:54][cH:53][c:52]([C:49]([C:48]([F:47])([F:59])[F:60])([CH3:50])[OH:51])[cH:57][cH:56]4)[C:14]3=[O:15])[CH2:16][CH2:17]2)[CH2:2][CH2:3]1Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-59abb84817724289be8e936ebe3732f2
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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