Piperonal → (Benzodioxol-5-yl)(3,5-dimethoxyphenyl)methanol

HRID 820664Notes

Reaction equation

HRID 820664 reaction equation
[Br:1][c:2]1[cH:3][c:4]([O:5][CH3:6])[cH:7][c:8]([O:9][CH3:10])[cH:11]1.[CH2:23]([Li:24])[CH2:25][CH2:26][CH3:27].[O:12]1[c:13]2[cH:14][cH:15][c:16]([CH:17]=[O:18])[cH:19][c:20]2[O:21][CH2:22]1.[O:28]1[CH2:29][CH2:30][O:31][c:32]2[c:33]1[cH:34][cH:35][c:36]([CH:38]([OH:39])[c:40]1[cH:41][c:42]([O:48][CH3:49])[cH:43][c:44]([O:46][CH3:47])[cH:45]1)[cH:37]2>>[O:28]1[CH2:30][O:31][c:32]2[c:33]1[cH:34][cH:35][c:36]([CH:38]([OH:39])[c:40]1[cH:41][c:42]([O:48][CH3:49])[cH:43][c:44]([O:46][CH3:47])[cH:45]1)[cH:37]2

Participants

5

Reactant 4

HCID 8438PiperonalHCID 6391871-Bromo-3,5-dimethoxybenzeneHCID 69202534(2,3-Dihydrobenzo[1,4]dioxin-6-yl)-(3,5-dimethoxyphenyl)methanolHCID 178418339Butyllithium

Product 1

HCID 69202706(Benzodioxol-5-yl)(3,5-dimethoxyphenyl)methanol

Sources & evidence

ORD record
ord-682d692569d7410c941efbfef8ff3eb1
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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