2-Methyl-4-methoxyaniline → 1-tert-Butoxycarbonyl-4-[2-(4-methoxy-2-methyl-phenylsulfanyl)-5-fluoro-phenyl]-piperidine-4-ol

HRID 820711Notes

Reaction equation

HRID 820711 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([c:14]2[c:15]([SH:21])[cH:16][cH:17][c:18]([F:20])[cH:19]2)([OH:22])[CH2:12][CH2:13]1.[CH3:33][O:34][c:35]1[cH:36][cH:37][c:38]([NH2:39])[c:40]([CH3:41])[cH:42]1.[I:23][c:24]1[c:25]([CH3:32])[cH:26][c:27]([O:30][CH3:31])[cH:28][cH:29]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([c:14]2[c:15]([S:21][c:24]3[c:25]([CH3:32])[cH:26][c:27]([O:30][CH3:31])[cH:28][cH:29]3)[cH:16][cH:17][c:18]([F:20])[cH:19]2)([OH:22])[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 76102-Methyl-4-methoxyanilineHCID 131401601-Iodo-4-methoxy-2-methylbenzeneHCID 686821134-(5-Fluoro-2-mercapto-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 686859691-tert-Butoxycarbonyl-4-[2-(4-methoxy-2-methyl-phenylsulfanyl)-5-fluoro-phenyl]-piperidine-4-ol

Sources & evidence

ORD record
ord-a6215aa7a9644db6823c0258da96f01f
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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