Dimethylamine → HCID 70817872, compound

HRID 82090Notes

Reaction equation

HRID 82090 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([NH:11][C:12]2[CH:13]=[C:14]([C:18]([C:20]3[C:28]4[CH:27]=[N:26][CH:25]=[N:24][C:23]=4[N:22]([CH:29]([CH3:33])[C:30]([OH:32])=O)[CH:21]=3)=[O:19])[CH:15]=[N:16][CH:17]=2)=[O:10])=[CH:4][CH:3]=1.[CH3:34][NH:35][CH3:36]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([NH:11][C:12]2[CH:13]=[C:14]([C:18]([C:20]3[C:28]4[CH:27]=[N:26][CH:25]=[N:24][C:23]=4[N:22]([CH:29]([CH3:33])[C:30]([N:35]([CH3:36])[CH3:34])=[O:32])[CH:21]=3)=[O:19])[CH:15]=[N:16][CH:17]=2)=[O:10])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 70817596HCID 70817596, compound

Product 1

HCID 70817872HCID 70817872, compound

Procedure

The title compound was prepared according to the method described for Example 34 at 50° C. using racemic 2-{5-[(5-{[(4-chlorophenyl)acetyl]amino}pyridin-3-yl)carbonyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl}propanoic acid (Example 354) and dimethylamine.

Workup

  1. customdescribed for Example 34 at 50° C.

Sources & evidence

ORD record
ord-76a72c689916475090f2747caf35c3a8
Source dataset
uspto-grants-2014_09
Patent number
US08846698B2

Reaction notes

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