HRID82094

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8083

Morpholine

C4H9NO

结构：CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(C=O)c3)c2)c2cncnc21

HCID86672072

未命名化合物

PRODUCTS

生成物

HCID283

Formic acid, ion(1-)

CHO2-

结构：CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(CN4CCOCC4)c3)c2)c2cncnc21.O=CO

HCID70817459

未命名化合物

PROCEDURE

实验过程

The title compound was prepared according to the method described for Example 266 using 2-(3-formylphenyl)-N-{5-[(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)carbonyl]pyridin-3-yl}acetamide (Preparation 192, 60 mg, 0.14 mmol) and morpholine to afford the title compound as a formate salt in 30% yield, 21 mg.

WORKUP

后处理

customThe title compound was prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8c4510a8fcba4267b49c6401294d1ada
来源数据集: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08846698B2
来源说明: uspto-grants-2014_09

反应 SMILES

[CH:1]([C:3]1[CH:4]=[C:5]([CH2:9][C:10]([NH:12][C:13]2[CH:14]=[N:15][CH:16]=[C:17]([C:19]([C:21]3[C:29]4[CH:28]=[N:27][CH:26]=[N:25][C:24]=4[N:23]([CH:30]([CH3:32])[CH3:31])[CH:22]=3)=[O:20])[CH:18]=2)=[O:11])[CH:6]=[CH:7][CH:8]=1)=[O:2].[NH:33]1[CH2:38][CH2:37][O:36][CH2:35][CH2:34]1>>[CH:19]([OH:20])=[O:36].[CH:30]([N:23]1[C:24]2[N:25]=[CH:26][N:27]=[CH:28][C:29]=2[C:21]([C:19]([C:17]2[CH:18]=[C:13]([NH:12][C:10](=[O:11])[CH2:9][C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([CH2:1][N:33]4[CH2:38][CH2:37][O:36][CH2:35][CH2:34]4)[CH:4]=3)[CH:14]=[N:15][CH:16]=2)=[O:20])=[CH:22]1)([CH3:31])[CH3:32].[CH:37]([O-:36])=[O:2]