Hydrochloric Acid → HCID 70817670, compound

Participants

Reaction Steps

4-benzoyl-Nalpha-(tert-butoxycarbonyl)-N-{5-[(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)carbonyl]pyridin-3-yl}-D-phenylalaninamide (Example 284, 20 mg, 0.03 mmol) was stirred with 10% hydrochloric acid in 1,4-dioxane (5 mL) at room temperature for 1 hour. The mixture was evaporated in vacuo and purified by preparative HPLC to afford the title compound as a gum in 56% yield, 9 mg.

Provenance & Evidence