反应详情

1-chloro-4-isocyanatobenzene (24 mg, 0.15 mmol) was added to (5-aminopyridin-3-yl)(7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone (30 mg, 0.12 mmol) (Preparation 232) in pyridine (1.0 mL). The mixture was stirred at room temperature overnight then evaporated in vacuo to yield the product as a crude residue. The crude residue was purified by preparative HPLC to afford the title compound in 49% yield, 24 mg.

1. customthen evaporated in vacuo
2. customto yield the product as a crude residue
3. customThe crude residue was purified by preparative HPLC