Methylamine hydrochloride → HCID 70817488, compound

Participants

Role	Name	HCID	Charge
Reactant	Methylamine hydrochloride	HCID 6364545	—
Reactant	Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)	HCID 9886157	—
Reactant	{5-[(5-{[(4-chlorophenyl)acetyl]amino}pyridin-3-yl)carbonyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl}acetic acid potassium salt	HCID 70817542	—
Solvent	Pyridine	HCID 1049	—
Solvent	Dichloromethane	HCID 6344	—
Product	HCID 70817488	HCID 70817488	—

Reaction Conditions

Temperature	25 °C

Reaction Steps

{5-[(5-{[(4-chlorophenyl)acetyl]amino}pyridin-3-yl)carbonyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl}acetic acid potassium salt (Example 307, 50 mg, 0.102 mmol) was added to a stirred solution of methyl amine hydrochloride (10.3 mg, 0.153 mmol) and HATU (58.2 mg, 0.153 mmol) in pyridine (2 mL). The resultant solution was stirred at 50° C. (reactivial) for 14 hours. The reaction was cooled to 25° C., diluted with DCM (5 mL) then quenched with saturated NaHCO3 (aq) (5 mL) and extracted with further DCM (3×5 mL).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08846698B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-a6c449939527490abd73d5d2127bfe1d
Source note	uspto-grants-2014_09