(5-Bromopyridin-2-yl)acetic acid → N-(5-{[2-amino-7-(1-hydroxy-2-methylpropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl}pyridin-3-yl)-2-(5-bromopyridin-2-yl)acetamide

Participants

Reaction Steps

The title compound was prepared according to the method described for Example 34 at 50° C. using [2-amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl](5-aminopyridin-3-yl)methanone (Preparation 48) and (5-bromopyridin-2-yl)acetic acid to afford the title compound as a yellow solid in 60% yield, 75 mg. LCMS (System 10): Rt=2.69 min; m/z 524 [M+H]+

Provenance & Evidence