1,4-Dioxane hydrochloride → 2-Hydroxy-N-[5-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-pyridin-3-yl]-2-phenyl-acetamide

Participants

Reaction Steps

To stirred solution of N-[5-(7-Isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-pyridin-3-yl]-2-phenyl-2-(tetrahydro-pyran-2-yloxy)-acetamide (60 mg, 0.12 mmol) (Preparation 237) in dioxane (1 mL) was added dioxane-HCl (1 mL of a 4N solution) at 00° C. The mixture was stirred at room temperature for 2 hours. All the volatiles were removed in vacuo and the solid obtained was triturated with diethyl ether to afford the title compound as a yellowish solid in 78% yield, 42 mg.

Provenance & Evidence