(5-Chloropyridin-2-yl)acetic acid → HCID 70817465, compound

Participants

Reaction Steps

The title compound was prepared according to the method described for Example 1 using (7-tert-butyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(5-methylamino-pyridin-3-yl)-methanone (Preparation 187) and (5-chloro-pyridin-2-yl)-acetic acid (see Preparation 90) to afford the title compound as off white solid in 21% yield, 25 mg. 1H NMR (400 MHz, DMSO-D6) δ: 1.78 (s, 9H), 3.32 (s, 3H), 3.77 (brs, 2H), 7.26 (br, 1H), 7.83 (br, 1H), 8.21 (s, 1H), 8.32 (s, 1H), 8.48 (s, 1H), 8.85 (s, 1H), 8.97 (s, 1H), 9.02 (s, 1H), 9.51 (s, 1H); LCMS (system 10): Rt=3.29 min; m/z 463.2 [M+H]+.

Provenance & Evidence