{2-amino-7-[1,1-dimethyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}(5-aminopyridin-3-yl)methanone → N-{5-[2-Amino-7-(2-hydroxy-1,1-dimethyl-ethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]-pyridin-3-yl}-2-(4-cyclopropyl-pyrazol-1-yl)-acetamide

Participants

Reaction Steps

The title compound was prepared according to the method described for Example 1 using {2-amino-7-[1,1-dimethyl-2-(tetrahydro-pyran-2-yloxy)-ethyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}-(5-amino-pyridin-3-yl)-methanone (Preparation 49) and (4-Cyclopropyl-pyrazol-1-yl)-acetic acid to afford the title compound as a white solid in 72% yield, 16.5 mg.

Provenance & Evidence