2-(Bromomethyl)tetrahydro-2H-pyran → 4'-bromo-1'-(oxolan-2-ylmethyl)spiro[5,6-dihydro-2H-furo[3,2-f][1]benzofuran-3,3'-indole]-2'-one

HRID 821352Notes

Reaction equation

HRID 821352 reaction equation
[Br:1][c:2]1[c:3]2[c:4]([cH:5][cH:6][cH:7]1)[NH:8][C:9](=[O:22])[C:10]21[c:11]2[c:12]([cH:15][c:16]3[c:20]([cH:21]2)[CH2:19][CH2:18][O:17]3)[O:13][CH2:14]1.[Br:40][CH2:41][CH:42]1[CH2:43][CH2:44][CH2:45][CH2:46][O:47]1.[CH3:23][c:24]1[cH:25][cH:26][c:27]([S:28]([O:29][CH2:34][CH:35]2[O:36][CH2:37][CH2:38][CH2:39]2)(=[O:30])=[O:31])[cH:32][cH:33]1>>[Br:1][c:2]1[c:3]2[c:4]([cH:5][cH:6][cH:7]1)[N:8]([CH2:34][CH:35]1[O:36][CH2:37][CH2:38][CH2:39]1)[C:9](=[O:22])[C:10]21[c:11]2[c:12]([cH:15][c:16]3[c:20]([cH:21]2)[CH2:19][CH2:18][O:17]3)[O:13][CH2:14]1

Participants

4

Reactant 3

HCID 1419172-(Bromomethyl)tetrahydro-2H-pyranHCID 4522871(Tetrahydrofuran-2-yl)methyl 4-methylbenzenesulfonateHCID 592634884'-bromo-5,6-dihydro-2H-spiro[benzofuro[6,5-b]furan-3,3'-indolin]-2'-one

Product 1

HCID 722686394'-bromo-1'-(oxolan-2-ylmethyl)spiro[5,6-dihydro-2H-furo[3,2-f][1]benzofuran-3,3'-indole]-2'-one

Sources & evidence

ORD record
ord-2c4b031a26904a99aad2b35f2275e18c
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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