2H-1,2,3-Benzotriazol-2-Ylacetic Acid → HCID 70817397, compound

HRID 82153Notes

Reaction equation

HRID 82153 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[C:18]3[CH:17]=[N:16][CH:15]=[N:14][C:13]=3[N:12]([C@@H:19]([CH3:28])[CH2:20][O:21][CH:22]3[CH2:27][CH2:26][CH2:25][CH2:24][O:23]3)[CH:11]=2)=[O:9])[CH:5]=[N:6][CH:7]=1.[N:29]1[N:30]([CH2:38][C:39](O)=[O:40])[N:31]=[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=12>>[N:29]1[N:30]([CH2:38][C:39]([NH:1][C:2]2[CH:7]=[N:6][CH:5]=[C:4]([C:8]([C:10]3[C:18]4[CH:17]=[N:16][CH:15]=[N:14][C:13]=4[N:12]([C@@H:19]([CH3:28])[CH2:20][O:21][CH:22]4[CH2:27][CH2:26][CH2:25][CH2:24][O:23]4)[CH:11]=3)=[O:9])[CH:3]=2)=[O:40])[N:31]=[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=12

Participants

3

Reactant 2

HCID 6455492H-1,2,3-Benzotriazol-2-Ylacetic AcidHCID 70817242(5-Aminopyridin-3-yl){7-[(1S)-1-methyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}methanone

Product 1

HCID 70817397HCID 70817397, compound

Procedure

The title compound was prepared according to the method described for Example 1 using (5-aminopyridin-3-yl){7-[(1S)-1-methyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}methanone (see Preparation 33) and benzotriazol-2-yl-acetic acid to afford the title compound as a yellow solid in 72% yield, 70 mg.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-0d42c5b1f37e4d2c8fb549d91a250d51
Source dataset
uspto-grants-2014_09
Patent number
US08846698B2

Reaction notes

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