HRID82153

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID645549

Benzotriazol-2-yl-acetic acid

C8H7N3O2

结构：C[C@@H](COC1CCCCO1)n1cc(C(=O)c2cncc(N)c2)c2cncnc21

HCID70817242

未命名化合物

PRODUCTS

生成物

结构：C[C@@H](COC1CCCCO1)n1cc(C(=O)c2cncc(NC(=O)Cn3nc4ccccc4n3)c2)c2cncnc21

HCID70817397

未命名化合物

PROCEDURE

实验过程

The title compound was prepared according to the method described for Example 1 using (5-aminopyridin-3-yl){7-[(1S)-1-methyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}methanone (see Preparation 33) and benzotriazol-2-yl-acetic acid to afford the title compound as a yellow solid in 72% yield, 70 mg.

WORKUP

后处理

customThe title compound was prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0d42c5b1f37e4d2c8fb549d91a250d51
来源数据集: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08846698B2
来源说明: uspto-grants-2014_09

反应 SMILES

[NH2:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[C:18]3[CH:17]=[N:16][CH:15]=[N:14][C:13]=3[N:12]([C@@H:19]([CH3:28])[CH2:20][O:21][CH:22]3[CH2:27][CH2:26][CH2:25][CH2:24][O:23]3)[CH:11]=2)=[O:9])[CH:5]=[N:6][CH:7]=1.[N:29]1[N:30]([CH2:38][C:39](O)=[O:40])[N:31]=[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=12>>[N:29]1[N:30]([CH2:38][C:39]([NH:1][C:2]2[CH:7]=[N:6][CH:5]=[C:4]([C:8]([C:10]3[C:18]4[CH:17]=[N:16][CH:15]=[N:14][C:13]=4[N:12]([C@@H:19]([CH3:28])[CH2:20][O:21][CH:22]4[CH2:27][CH2:26][CH2:25][CH2:24][O:23]4)[CH:11]=3)=[O:9])[CH:3]=2)=[O:40])[N:31]=[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=12