1-(5-Chloro-2-trifluoromethylbenzyl)-7-iodo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine → [4-[1-[[5-Chloro-2-(trifluoromethyl)phenyl]methyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]methanone

HRID 821545Notes

Reaction equation

HRID 821545 reaction equation
[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:20]([F:21])([F:22])[F:23])[c:6]([CH2:7][N:8]2[c:9]3[c:10]([n:14][cH:15][c:16]([I:18])[cH:17]3)[NH:11][CH2:12][CH2:13]2)[cH:19]1.[N:24]1([CH:29]2[CH2:30][CH2:31][N:32]([C:35](=[O:36])[c:37]3[cH:38][cH:39][c:40]([B:43]4[O:44][C:45]([CH3:46])([CH3:47])[C:48]([CH3:49])([CH3:50])[O:51]4)[cH:41][cH:42]3)[CH2:33][CH2:34]2)[CH2:25][CH2:26][CH2:27][CH2:28]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:20]([F:21])([F:22])[F:23])[c:6]([CH2:7][N:8]2[c:9]3[c:10]([n:14][cH:15][c:16](-[c:40]4[cH:39][cH:38][c:37]([C:35]([N:32]5[CH2:31][CH2:30][CH:29]([N:24]6[CH2:25][CH2:26][CH2:27][CH2:28]6)[CH2:34][CH2:33]5)=[O:36])[cH:42][cH:41]4)[cH:17]3)[NH:11][CH2:12][CH2:13]2)[cH:19]1

Participants

3

Reactant 2

HCID 578860851-(5-Chloro-2-trifluoromethylbenzyl)-7-iodo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazineHCID 57886103[4-(Pyrrolidin-1-yl)piperidin-1-yl][4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanone

Product 1

HCID 46871638[4-[1-[[5-Chloro-2-(trifluoromethyl)phenyl]methyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]methanone

Sources & evidence

ORD record
ord-c6b6449ef6964259a751d9803b8685ce
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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